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"DEW003", an innovative biotherapeutic independently developed by Darwin, is a nano-protein particle polymer that reduces abnormal protein deposits in brain tissue, such as TDP-43, Aβ, and pTau. It alleviates neurotoxicity, neuroinflammation, endoplasmic reticulum stress, and mitochondrial damage, while enhancing glial cell nutrition and modulation of neurons. It restores nervous system homeostasis, prevents neuron death, and promotes axonal transport, growth, and synapse formation.

A phase I clinical trial of Aritoprotein injection for mild to moderate Alzheimer's disease is underway at the Department of Neurology, Yuquan Hospital (Tsinghua University Hospital of Integrated Traditional and Western Medicine). Approved by the hospital's medical ethics committee (Chinese Clinical Trial Registry Number: ChiCTR2400082310), the study is led by Dr. Qiao Liyan and involves 10 participants meeting the NIA-AA diagnostic criteria for Alzheimer's, with stable caregivers involved throughout.

This study is groundbreaking as Aritoprotein is the first protein polymer biotherapeutic for Alzheimer's, filling a critical gap. Promising preclinical results have raised hopes for patients, and we will continue optimizing the drug.

Dr. Qiao Liyan: Chief Physician, Tsinghua University Professor, and Ph.D. supervisor. She is the Director of the Department of Neurology at Yuquan Hospital and a postdoctoral fellow in neuropathology at the University of Alabama. With over 20 years of clinical experience, she specializes in diagnosing and treating central nervous system degenerative diseases (cognitive impairment, Alzheimer's), autoimmune neurological diseases (myasthenia gravis, multiple sclerosis), neurological infections, and cerebrovascular diseases. She holds several academic positions, including Director of the Neurocognitive Committee of the Alzheimer's Disease Prevention Association and Deputy Director of the Beijing Neurodegenerative Disease Committee's Cognitive Impairment Full-Process Management Committee. She has published over 60 papers and several books, undertaken multiple research projects, and received numerous awards, including the Beijing Science and Technology Progress Third Prize and the 2018 Sixth Beijing Outstanding Physician Award.

Alzheimer's Disease: A progressive neurodegenerative disorder primarily affecting memory, thinking, and behavior, it is the most common cause of dementia in older adults. Key features include neuron loss and brain atrophy, leading to memory decline, cognitive impairment, and behavioral changes. While the exact cause is unknown, genetic, abnormal protein aggregation, and neurotransmitter imbalance factors are implicated. Though incurable, treatments can help manage symptoms and improve quality of life.

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